Torsades de Pointes

Prolonged  Q-T Syndrome

 

 Categories of Drugs to Avoid

Browse Drug List  Overview  Counteractive Measures  Recommended Books
Sedatives & Insomnia

Zomig & Hydralazine

Mycins & Mycetins
Antibiotics, antivirals, anti-infectives Floxacins Antifungals & Conazoles
Tricyclics & other antidepressants Anti-anginal Anti-arrhythmics
Anti-Pain or Narcotic abuse anti-cancer Anti-Marlarial
Bronchodialators & inhalers Diuretics CNS Stimulants
Appetite Suppressant  Endocrine anti-convulsant
Controlled Substances & street drugs Muscle relaxant Immunosuppressant
Alpha Blocker, Prostatic Hyperplasia, anti-hypertensives Uterine relaxant & Premature labor preventative Cholinesterase inhibitor, Dementia, Alzheimer's
Phosphodiesterase inhibitor & Vasodilator Antiviral, Dopaminergic & Parkinsons Norepinephrine, Reuptake inhibitor
Methadone & Droperidol Gastrointestinal, antinausea, urinary Antipsychotics & anti-mania

Catecholamine, heart failure, shock, vasoconstrictor, anaphylaxis, decongestants & Allergy

 

List of Drugs which can cause sudden cardiac death in a patient with Torsades

Each person reacts differently to these drugs. I can take many of these drugs without problems, while others cannot.  My Imdur also protects me because it is a pill form of Nitroglycerine which stops & prevents Torsades

  • Zomig Deadly! Deadly! Deadly!!!

    • I cannot overemphasize how dangerous this drug is for Torsades and prolonged Q-T patients. This is the drug, which caused my sudden cardiac death and more than 100 Torsades episodes. A holter monitor recorded my sudden cardiac death caused by Zomig and has been thoroughly documented in my medical records. 

    • It has been falsely omitted from Torsades lists but 

      • Donít take any chances with this drug.  

    • Some cardiologists have suggested that Imitrex which is another migraine medication may share enough similarities to pose a similar risk in Torsades and prolonged Q-T patients.  

  •  Hydralazine (Apresoline) Deadly! Deadly! Deadly!!!

    • This new blood pressure drug nearly killed me last year. My heart went into  rapid onset tachycardia and reached 171 bpm before I could stop it with nitro, benadryl, Imdur & Bystolic (a beta blocker). It  took everything I had to stop the Torsades attack which occurred within 30 minutes of taking Hydralazine.  My defibrillator is set at 215 bpm because I wish to avoid being shocked if possible.  I understand 215 has now has adopted as or standard for all defibrillator implant devices.  Interesting  that everyone chose my requested setting. My original setting by another doctor was 150. The rapid onset tachycardia was a horrible experience & a close call. I suffered terribly. I was not taking Imdur at the time. I do now.

    • Hydralazine is a BAD, BAD, DEADLY drug for anyone with Torsades.

    Droperidol (Inapsine) Deadly! Deadly! Deadly!!!

    • This antinausea drug  is a nasty bad Torsades killer. 

    • NEVER take this drug.  

    • Don't trust it even if you are undiagnosed. 

    • It nearly killed me in  1991 when administered for an endoscopy by the doctor without a proper anesthesiologist. The doctor panicked & nearly did not stop the episode. He administered Benadryl.  He  failed to follow my instructions for Vistaril & when I began to have reactions, I asked if he used  Vistaril. He responded it was like Vistaril.  

    • Internet warnings: http://www.rxlist.com/inapsine-drug.htm

    • I had adamantly warned him prior to the endoscopy not to substitute because of my past bad reactions to drugs. He did Not listen & nearly killed me.  Nor was he properly prepared with nitro meds. This is why you need to insist on a qualified anesthesiologist or find a doctor who will use one.  Even with diligence, you have to double & triple check because they don't listen & consider the patients opinions are beneath their own.

    • This is one of the worst Torsades drugs and is supposed to be removed from the market.

    • But I can now see it is still available. But any doctor or hospital which is dumb enough to order this drug is facing a huge liability if someone dies after all the huge warnings about Torsades flooding the medical sites. It should be banned. Shame on the FDA & the pharmaceutical company.

    • My torsades was undiagnosed at the time but my presumed esophageal spasms allowed me to obtain the life saving nitroglycerine which kept me alive until the deadly episode in 2001 when I  was wearing the holter monitor.

    • My cardiologist in 2001 read the 91 report & immediately recognized this drug as deadly to Torsades patients. It was not an allergic reaction & I'm lucky to be alive.  

    • Benadryl is good but only if concurrently used with Nitro for a Torsades reaction.  Nitro stops the episodes

    • Without Nitro you are shooting craps with your life.

  • Methadone Deadly! Deadly! Deadly!!!

    • This is the drug which killed Anna Nicole Smith and her son.  

    • I believe they both had undiagnosed Torsades. 

    • Her surviving daughter is still at risk. 

    • Dr Cyril Wecht & the Broward county coroner tried to tell the press that Anna only had therapeutic levels of medicine (meaning she did not OD) in her blood. Both men agreed that a heart irregularity like Torsades was likely. There are no symptoms to diagnose for Torsades except during an episode. Not even after death. 

    • Especially since both mother & son had taken methadone but did not OD. They took prescribed doses. That is a standard Torsades condition. 

      • Heredity multiple family deaths & use of a Torsades drug. 

      • Especially Methadone. 

      • Multiple family deaths.  Especially deaths at early age

    • But the press refused to listen. They assume if you brought 20 bottles of meds with you, then you are taking all of them. When traveling, you bring everything with you in Case you need it. Even if you don't take them. Just "as needed". The press refused to listen to either coroner.

    • Dr Wecht even tried to warn Anna after we talked about her son & Torsades. But she was on her boat, enroute. She died so fast, we were too late. 

    • No one knows her daughter remains at risk due to heredity. 

    • The press invented all kinds of crazy drug abuse stories & did not comprehend therapeutic levels or bringing extra meds if needed. The public also does not understand that British & Canadian Countries use Methadone instead of morphine for pain. The US does not use it except for drug addicts. So that's what people believe. 

    • However, that places the British & Canadian citizens at highest risk of Torsades deaths. They need to change to Morphine or other pain med & get rid of the deadly Methadone.

    • Do Not use this drug!

    • Demand an alternate pain med. Your life may depend on it if you don't know you have Torsades. It is like playing Russian Roulette with a ticking bomb.

  • Vistaril (Hydroxyzine)  I can take this drug safely

    • antihistamine. Anti anxiety, surgery

    • Listed on internet as Long QT avoidance. Torsades risk.

  • Mycins & Mycetins

    • Clarithromycin (Biaxin)  I can take this drug safely

    • Erythromycin I can take this drug safely

    • Azithromycin  I can take this drug safely

    • Roxithromycin

    • Telithromycin  

    • From personal experience, I would also recommend avoiding Terramycin, Streptomycin & Chlormycetin to the list of drugs, which affected my Torsades condition. I also had anaphylactic reaction to each injection of these drugs as a child.  However, Torsades was not discovered until the mid 60's. My hospital records show I had tachycardia at age 2 after a streptomycin injection. Torsades was unknown so they called it anaphylactic.

    • Vancomycin. required Imdur & Benadryl & Bystolic to prevent onset of cardiac arrhythmias & enabled me to take the IV drug  when I had septicemia. When used without prevention measures, I had a distressing cardiac reaction within a minute or two on IV and had to be withdrawn. 

    • The prior use of Imdur ER & Benadryl & Bystolic prevented a recurrence of cardiac arrhythmias and all owed me to safely take IV Vancomycin. I also had them reduce IV to very low flow.

  • Floxacins

    • Levofloxacin (Levaquin) I can take this drug safely

    • monifloxacin, Ofloxacin I can take this drug safely

    • Ciprofloxacin (Cipro) I can take this drug safely

    • Sparfloxacin

    • gatifloxicin (Tequin)

    • Gemifloxacin

  • Other antibiotics. antivirals & anti-infectives

    • Pentamidine (Nebupent)

    • Amantadine

    • Trimethoprim-sulfa (Sulfa) (Bactrim) I can take this drug safely

    • Foscarnet

  • Antifungals & conazoles

    • Voriconazole (Vfend)

    • fluconazole (Diflucan) I can take this drug safely

    • Itraconazole

    • Ketoconazole

  • Anti-arrhythmics

    • Amiodarone (Cordarone)

    • Disopyramide (Norpace)

    • Dofetilide (Tikosyn)

    • Ibutilide (Covert)

    • Procainamide (Procan)

    • Quinidine, Sotalol (Betapace)

    • Flecainide (Tambocor)

    • Dopamine

    • Mexiletine

  • Tricyclic & other Antidepressants

    • Venlaflaxine (Effexor)

    • Amitriptylene (Elavil)

    • Amoxapine

    • Citalopram (Celexa)

    • Clomipramine (Anafranil)

    • Clozapine

    • Desipramine (Pertofrane)

    • Doxepin (Sinequan)

    • Fluoxetine (Prozac) (Sarafem)

    • Imipramine (Norfranil)

    • Nortriptyline (Pamelor)

    • Paroxetine (Paxil)

    • Protriptyline (Vivactil)

    • Sertraline (Zoloft)

    • Trimipramine (Surmontil)  

    • Vistaril (Hydroxyzine) I can take this drug safely

  • Antipsychotics & Anti-mania

    • Chlorpromazine (Thorazine)

    • Haloperidol (Haldol) Bad drug! Don't use. 

    • Mesoridazine (Serentil)

    • Pimozide (Orap)

    • Theoridazine (Melloril)

    • Clozapine (Clozaril)

    • Lithium, Quetiapine (Seroquel)

    • Risperidone (Risperdal)

    • Ziprasidone (Geodon)

  • Gastrointestinal, Anti-Nausea, & Urinary

    • Cisapride (Propulsid)

    • Dolasetron (Anzemet)

    • Droperidol (Inapsine) Deadly! Deadly! Deadly!!!

    • Domperidone (Motilium)

    • Granisetron (Kytril)

    • Ondansetron (Zofran) I can take this drug safely

    • Solifenacin (VESIcare)

    • Tolterodine (Detrol)

  • Antiviral, Dopaminergic & Parkinsons

    • Amantadine (Symmetrel)

    • Foscarnet (Foscavir)

  • Anti-anginal

    • Bepridil (Vascor)

    • Ranolazine (Ranexa)

  • Anti-cancer

    • Arsenic Trioxide (Trisenox)

    • Tamoxifen (Nolvadex)

  • Pain & Narcotic abuse

    • Levomethadyl (Orlaam)

    • Methadone Deadly! Deadly! Deadly!!!

  • Anti-Malarial

    • Chloroquine (Arelan)

    • Halofantrine (Halfan)

  • CNS Stimulants

    • Amphetamine (Adderall)

    • Dexmethyphenidate (Focalin)

    • Dextroamphetamine (Dexadrine)

    • Methyphenidate (Ritalin) (Concerta)

  • Anti-convulsant

    • Felbamate (Felbatrol)

    • Fosphenytoin (Cerebyx)

  • Cholinesterase inhibitor, Dementia, Alzheimer's

    • Galantamine (Reminyl)

  • Sedatives & insomnia

    •   Chloral hydrate (Noctec)

  • Diuretics

    • Indapamide (Lozol)

  • Endocrine

    • Octreotide (Sandostatin)

  • Immunosuppressant

    • Tacrolimus (Prograf)

  • Alpha Blocker, Prostatic Hyperplasia, anti-hypertensives

    • Alfuzosin (Uroxatral)

    • Isradipine (Dynacirc)

    • Moexipril/HCZT (Uniretic)

    • Nicardipine (Cardene)

  • Muscle relaxant

    • Tizanidine (Zanaflex)

  • Uterine relaxant & Premature labor preventative

    • Ritodrine (Yutopar)

  • Catecholamine, heart failure, shock, vasoconstrictor, anaphylaxis, decongestants & Allergic reactions

    • Dobutamine (Dobutrex)

    • Epinephrine Bad reaction dental anesthetic additive.

    • Isoproternol (Isupres)

    • Midodrine (ProAmatine)

    • Norepinephrine (Levophed)

    • Phenylephrine (Neosynephrin) I can take this drug safely

    • phenylpropanolomine (Dexatrim) I can take this drug safely

    • Pseudoephedrine (Sudafed) I can take this drug safely

    • Vistaril (Hydroxyzine) I can take this drug safely

  • Norepinephrine, Reuptake inhibitor

    • Atomoxetine (Strattera)

  • Phosphodiesterase inhibitor & Vasodilator

    • Vardenafil (Levitra)

    • Hydralazine Deadly! Deadly! Deadly!!!

  • Bronchodialators & inhalers

    • Albuterol (Ventolin) (Proventil) I can take this drug safely

    • Ephedrine I can take this drug safely

    • Levabuterol (Xopenex)

    • Metaproterenol (Metaprel)

    • Salmeterol (Serevent)

    • Terbutaline (Brethine)

  • Appetite suppressant

    • Fenfluramine (Pondimin)

    • Phentermine (Fastin) I can take this drug safely

    • phenylpropanolomine (Dexatrim) I can take this drug safely

    • Sibutramine (Meridia)

  • Controlled Substances & street drugs

    • Cocaine

    • Methadone Deadly! Deadly! Deadly!!!

    • Amphetamines (also see CNS stimulants)

  • Other medications 

    • based on my personal experience, I recommend avoiding   

    • Zomig, Hydralazine, Droperidol Deadly! Deadly! Deadly!!!

    • Also avoid valium, carbocaine with ephedrine, Demerol, Toprol

 

 

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